Abstract |
Transdermal Delivery System ( TDS) is a liquid formulation which can be applied to the skin via a metered pump spray to deliver drug across skin. This placebo controlled, double blind trial compared anaesthetic properties of two TDS systems ( TDS alpha and TDS beta) with placebo. The active and placebo treatments were applied to the dorsum of the hands, bilaterally and simultaneously for 5 min on 100 healthy volunteers. Following cannulation, pain perception was measured using the verbal rating score (VRS) and visual analogue score (VAS). Lidocaine plasma levels were assessed at 0 and 2 h. The VRS and VAS results show that TDS beta significantly decreased pain score compared to placebo (p < 0.02). Blood lidocaine at 2 h post application was also higher for TDS beta than for TDS alpha, suggesting that a 5 min application of TDS beta was effective in delivering local anaesthetic and accelerating the onset of skin anaesthesia prior to venous cannulation in adults.
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Authors | A T Tucker, Z Chik, L Michaels, K Kirby, M P Seed, A Johnston, C A S Alam |
Journal | Anaesthesia
(Anaesthesia)
Vol. 61
Issue 2
Pg. 123-6
(Feb 2006)
ISSN: 0003-2409 [Print] England |
PMID | 16430563
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Anesthetics, Local
- Lidocaine
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Topics |
- Administration, Cutaneous
- Adult
- Anesthesia, Local
(methods)
- Anesthetics, Local
(administration & dosage, blood)
- Chemistry, Pharmaceutical
- Double-Blind Method
- Drug Delivery Systems
- Female
- Hand
- Humans
- Lidocaine
(administration & dosage, blood)
- Male
- Pain
(etiology, prevention & control)
- Pain Measurement
(methods)
- Phlebotomy
(adverse effects, methods)
- Prospective Studies
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