Respiratory syncytial virus G protein and G protein CX3C motif adversely affect CX3CR1+ T cell responses.

Abstract

Interactions between fractalkine (CX3CL1) and its receptor, CX3CR1, mediate leukocyte adhesion, activation, and trafficking. The respiratory syncytial virus (RSV) G protein has a CX3C chemokine motif that can bind CX3CR1 and modify CXCL1-mediated responses. In this study, we show that expression of the RSV G protein or the G protein CX3C motif during infection is associated with reduced CX3CR1+ T cell trafficking to the lung, reduced frequencies of RSV-specific, MHC class I-restricted IFN-gamma-expressing cells, and lower numbers of IL-4- and CX3CL1-expressing cells. In addition, we show that CX3CR1+ cells constitute a major component of the cytotoxic response to RSV infection. These results suggest that G protein and the G protein CX3C motif reduce the antiviral T cell response to RSV infection.

• Authors: Jennifer Harcourt, Rene Alvarez, Les P Jones, Christine Henderson, Larry J Anderson, Ralph A Tripp
• Journal: Journal of immunology (Baltimore, Md. : 1950) (J Immunol) Vol. 176 Issue 3 Pg. 1600-8 (Feb 01 2006) ISSN: 0022-1767 [Print] United States
• PMID: 16424189 (Publication Type: Journal Article)

Chemical References

• CX3C Chemokine Receptor 1
• Chemokines, CX3C
• Cx3cr1 protein, mouse
• Receptors, Chemokine
• Viral Envelope Proteins
• attachment protein G
• Interleukin-4
• Interferon-gamma

Topics

• Amino Acid Motifs
• Animals
• CD4-Positive T-Lymphocytes (immunology, metabolism)
• CD8-Positive T-Lymphocytes (metabolism)
• CX3C Chemokine Receptor 1
• Cell Migration Inhibition
• Cell Movement (immunology)
• Cells, Cultured
• Chemokines, CX3C (biosynthesis, genetics)
• Female
• Interferon-gamma (biosynthesis, genetics)
• Interleukin-4 (metabolism)
• Lung (immunology, pathology)
• Mice
• Mice, Inbred BALB C
• Receptors, Chemokine (antagonists & inhibitors, biosynthesis)
• Respiratory Syncytial Viruses (genetics, immunology)
• T-Lymphocytes (immunology, metabolism, pathology, virology)
• Viral Envelope Proteins (biosynthesis, genetics, immunology)