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Morphometric and microscopic evaluation of the effect of solution of acetazolamide as an intracanal therapeutic agent in late reimplanted rat teeth.

Abstract
The use of substances that inhibit root resorption may be an alternative for cases of unsuccessful reimplants. Hence, the purpose of this study was to test a solution of acetazolamide, a resorption inhibitor, as an intracanal therapeutic agent for late reimplanted teeth. Thirty rat maxillary right central incisors were avulsed and kept dry for 30 min. The teeth were instrumented, and the root surfaces treated with 1% hypochlorite solution followed by application of 2% sodium fluoride. Thereafter, the teeth were divided into two groups according to the intracanal dressing: Group I, solution of acetazolamide and Group II, calcium hydroxide paste. Teeth were then reimplanted in their respective sockets. The animals were killed at 15, 30, and 60 days after reimplantation and the samples processed for morphometric and microscopic analysis. The results showed that calcium hydroxide paste limited root resorption, even though not avoiding it. In contrast, no root resorption was observed after 60 days in the acetazolamide group, confirming the efficacy of the substance in inhibiting root resorption.
AuthorsGraziela Garrido Mori, Roberto Brandão Garcia, Ivaldo Gomes de Moraes
JournalDental traumatology : official publication of International Association for Dental Traumatology (Dent Traumatol) Vol. 22 Issue 1 Pg. 36-40 (Feb 2006) ISSN: 1600-4469 [Print] Denmark
PMID16422757 (Publication Type: Evaluation Study, Journal Article)
Chemical References
  • Carbonic Anhydrase Inhibitors
  • Root Canal Filling Materials
  • Root Canal Irrigants
  • Acetazolamide
  • Calcium Hydroxide
Topics
  • Acetazolamide (therapeutic use)
  • Animals
  • Calcium Hydroxide (therapeutic use)
  • Carbonic Anhydrase Inhibitors (therapeutic use)
  • Desiccation
  • Male
  • Rats
  • Rats, Wistar
  • Root Canal Filling Materials (therapeutic use)
  • Root Canal Irrigants (therapeutic use)
  • Root Resorption (prevention & control)
  • Statistics, Nonparametric
  • Tooth Replantation

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