Clinical features and outcomes of HLA-b27-positive and HLA-B27-negative acute anterior uveitis in a Turkish patient population.

Abstract

PURPOSE:

To compare the clinical features and outcomes of HLA-B27-positive and HLA-B27-negative acute anterior uveitis (AAU) in a large Turkish patient population.

METHODS:

Forty-four patients with HLA-B27-positive AAU and 65 with HLA-B27-negative AAU were reviewed retrospectively. HLA-B27 typing, gender, laterality, clinical features (fibrinous reaction, hypopyon formation), ocular complications, medical treatment, and final visual acuity were recorded. Statistical analyses included Student's t-test, Fisher's exact test, Yate's corrected Chi2 test, and Mann-Whitney U test. A p-value of <0.05 was considered statistically significant.

RESULTS:

Forty percent of all patients with AAU were found to be positive for HLA-B27 antigen. HLA-B27-positive AAU was significantly more common in males and HLA-B27-negative AAU in females. Unilateral or bilateral alternating AAU as well as fibrinous reaction and hypopyon formation were more common in HLA-B27-positive patients. Posterior iris synechiae and cataract formation were more common and systemic immunosuppressive agents were exclusively required in patients with HLA-B27-negative AAU. Visual outcome did not differ significantly between the HLA-B27-positive and HLA-B27-negative groups.

CONCLUSIONS:

HLA-B27 association is less common in Turkish patients with AAU than in other populations reported in the literature. Although distinct features of HLA-B27 uveitis were confirmed in our study, visual outcome did not differ from idiopathic AAU. Therefore, we believe that HLA-B27 typing in patients with AAU helps the clinician with the diagnosis. However, it has a limited value in determining the prognosis.

• Authors: Samuray Tuncer, Yakubu Seidu Adam, Meri Urgancioglu, Ilknur Tugal-Tutkun
• Journal: Ocular immunology and inflammation (Ocul Immunol Inflamm) 2005 Sep-Oct Vol. 13 Issue 5 Pg. 367-73 ISSN: 0927-3948 [Print] England
• PMID: 16419422 (Publication Type: Comparative Study, Journal Article)

Chemical References

• HLA-B27 Antigen
• Immunosuppressive Agents

Topics

• Acute Disease
• Adult
• Female
• Follow-Up Studies
• HLA-B27 Antigen (immunology)
• Humans
• Immunosuppressive Agents (therapeutic use)
• Incidence
• Male
• Prognosis
• Retrospective Studies
• Seroepidemiologic Studies
• Turkey (epidemiology)
• Uveitis, Anterior (diagnosis, drug therapy, immunology)
• Visual Acuity