Abstract |
The present study was performed to investigate the protective effects of granulocyte macrophage-colony stimulating factor ( GM-CSF) against ulcerative mucositis in hamster buccal pouch. GM-CSF was topically administered to the buccal pouches of hamsters with two different doses of 5 and 20 microg/ml. The treatment of GM-CSF led to rapid healing effects in gross and histopathological findings. It decreased expression of pro-inflammatory cytokine mRNA levels in the mucosal tissue of buccal pouches. Also GM-CSF-treated animals showed high numbers of Ki-67 positive cells in basal cell layer. These results suggest that GM-CSF provided excellent healing effects to ulcerative mucositis in the buccal pouch of hamster.
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Authors | Sun-A Cho, Jong-Hwan Park, Seung-Hyeok Seok, Jae-Hyeon Juhn, Seong-Jin Kim, Hyi-Jeong Ji, Youn-Sung Choo, Jae-Hak Park |
Journal | Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
(Exp Toxicol Pathol)
Vol. 57
Issue 4
Pg. 321-8
(Mar 2006)
ISSN: 0940-2993 [Print] Germany |
PMID | 16414253
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Ulcer Agents
- Biomarkers
- Recombinant Proteins
- Granulocyte-Macrophage Colony-Stimulating Factor
- Fluorouracil
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Topics |
- Administration, Topical
- Animals
- Anti-Ulcer Agents
(therapeutic use)
- Biomarkers
(metabolism)
- Cricetinae
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Fluorouracil
(toxicity)
- Granulocyte-Macrophage Colony-Stimulating Factor
(therapeutic use)
- Male
- Mesocricetus
- Mouth Mucosa
(drug effects, metabolism, pathology)
- Oral Ulcer
(chemically induced, drug therapy, pathology)
- Recombinant Proteins
- Stomatitis
(chemically induced, drug therapy, pathology)
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