Abstract | AIM: To investigate the prevalence of Porphyromonas gingivalis in root canals of infected teeth with periapical abscesses and to investigate the antimicrobial susceptibility of this species to some frequently prescribed antibiotics. METHODOLOGY: RESULTS: A total of 352 individual strains, belonging to 69 different species, were isolated. Eighty three percent of the strains were strict anaerobes and 47.5% of the isolated bacteria were Gram-negative. Porphyromonas gingivalis was found in 20 root canals and was most frequently found in symptomatic cases. Statistically, the presence of P. gingivalis was related to purulent exudates and pain on palpation (both P < 0.05). All P. gingivalis strains were sensitive to amoxicillin, amoxicillin + clavulanate, cephaclor, clindamycin, benzylpenicyllin, metronidazole and tetracycline. The lowest range of minimum inhibitory concentration (MIC) (0.026-0.125 microg mL(-1)) was observed against amoxicillin + clavulanate and clindamycin. The lowest MIC 90 was observed against clindamycin (0.064 microg mL(-1)). One strain was resistant to erythromycin and eight strains were resistant to azythromycin. CONCLUSION:
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Authors | R C Jacinto, B P F A Gomes, H N Shah, C C Ferraz, A A Zaia, F J Souza-Filho |
Journal | International endodontic journal
(Int Endod J)
Vol. 39
Issue 1
Pg. 62-70
(Jan 2006)
ISSN: 0143-2885 [Print] England |
PMID | 16409330
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Animals
- Anti-Infective Agents
(pharmacology)
- Cattle
- Child
- Dental Pulp Cavity
(microbiology)
- Female
- Humans
- Male
- Microbial Sensitivity Tests
(methods)
- Middle Aged
- Periapical Abscess
(microbiology)
- Porphyromonas gingivalis
(drug effects)
- Prevalence
- Pulpitis
(microbiology)
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