Synthesis and preliminary antiproliferative evaluation of 1,3,9-triazacyclopenta[b]fluorene derivatives.

Abstract

Novel 1,3,9-triazacyclopenta[b]fluorene-4,10-diones and 1,3,9-triazacyclopenta[b]fluorene, analogue of ellipticine, were synthesised, and evaluated in vitro for their antiproliferative activity on various breast cancer cell lines.

• Authors: Gwenaelle Desforges, Laurent Picot, Cyril Montagne, Valérie Thiéry, Thierry Besson, Benoit Joseph
• Journal: Journal of enzyme inhibition and medicinal chemistry (J Enzyme Inhib Med Chem) Vol. 20 Issue 6 Pg. 569-74 (Dec 2005) ISSN: 1475-6366 [Print] England
• PMID: 16408792 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Carbazoles
• Fluorenes
• Imidazoles

Topics

• Breast Neoplasms (drug therapy)
• Carbazoles (chemical synthesis, chemistry, pharmacology)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Drug Screening Assays, Antitumor
• Female
• Fluorenes (chemical synthesis, chemistry, pharmacology)
• Humans
• Imidazoles (chemical synthesis, chemistry, pharmacology)
• In Vitro Techniques
• Molecular Structure
• Structure-Activity Relationship