Impact of radiotherapy for pediatric CNS atypical teratoid/rhabdoid tumor (single institute experience).

Abstract

PURPOSE:

To assess outcomes and prognostic factors in radiotherapy of pediatric central nervous system atypical teratoid/rhabdoid tumor (AT/RT).

METHODS AND MATERIALS:

Seventeen patients with central nervous system AT/RT were retrospectively reviewed after curative radiotherapy as primary or adjuvant therapy between January 1990 and December 2003. Overall and failure-free survival rates were calculated using the Kaplan-Meier method. The log-rank method was used to compare the effects of dosage (>50 Gy or < or =50 Gy) and treatment duration (>45 days or < or =45 days). Multivariate analysis was performed for prognostic factors.

RESULTS:

Median overall survival and failure-free survival were 17 and 11 months, respectively. The 3 longest-surviving patients were older, underwent gross tumor removal, and completed both craniospinal and focal boost irradiation. Multivariate analysis revealed a significant relationship between the following: overall survival and performance status (p = 0.019), failure-free survival and total irradiation dose (p = 0.037), time interval between surgery and radiotherapy initiation (p = 0.031), and time interval between surgery and radiotherapy end point (p = 0.047).

CONCLUSION:

Radiotherapy is crucial in the treatment of AT/RT. We recommend initiating radiotherapy immediately postoperatively and before systemic chemotherapy in pediatric patients > or =3 years of age.

• Authors: Yi-Wei Chen, Tai-Tong Wong, Donald Ming-Tak Ho, Pin-I Huang, Kai-Ping Chang, Cheng-Ying Shiau, Sang-Hue Yen
• Journal: International journal of radiation oncology, biology, physics (Int J Radiat Oncol Biol Phys) Vol. 64 Issue 4 Pg. 1038-43 (Mar 15 2006) ISSN: 0360-3016 [Print] United States
• PMID: 16406394 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Adolescent
• Adult
• Brain Neoplasms (radiotherapy, surgery)
• Child
• Child, Preschool
• Cranial Irradiation (methods)
• Disease-Free Survival
• Female
• Humans
• Male
• Multivariate Analysis
• Radiotherapy Dosage
• Retrospective Studies
• Rhabdoid Tumor (radiotherapy, surgery)
• Survival Analysis
• Teratoma (radiotherapy, surgery)