Orlistat in the treatment of overweight or obese Chinese patients with newly diagnosed Type 2 diabetes.

Abstract

AIMS:

Orlistat promotes weight loss in overweight and obese patients with Type 2 diabetes receiving hypoglycaemic treatment, but has not been investigated in patients with newly diagnosed and previously untreated Type 2 diabetes. We evaluated the efficacy of 24 weeks' treatment with orlistat, combined with a mildly reduced-calorie diet, on weight loss and glycaemic control in overweight and obese patients with newly diagnosed and previously untreated Type 2 diabetes.

METHODS:

A total of 249 Chinese patients (body mass index 25-40 kg/m2) with recently diagnosed Type 2 diabetes were randomized to placebo (n=124) or orlistat 120 mg (n=125) three times daily; all patients followed a mildly reduced-calorie diet. Patients had HbA1c 6.5-8.5% (mean 7.3%) and had never received any glucose-lowering medication.

RESULTS:

Orlistat-treated patients achieved significantly greater weight loss at the study end than placebo-treated patients (-5.4 vs. -2.4 kg; P<0.0001). More orlistat than placebo patients lost>or=5% (60.5 vs. 26.8%; P<0.0001) and >or=10% of their body weight (20.2 vs. 4.9%; P=0.0002). A significantly greater decrease in HbA(1c) from baseline was obtained with orlistat than placebo (-1.0 vs. -0.6%; P=0.0008). Orlistat-treated patients achieved a significantly greater decrease in fasting plasma glucose (-1.3 vs. -0.5 mmol/l; P=0.0003) and in the 2-h oral glucose tolerance test (-4.1 vs. -1.4 mmol/l; P<0.0001) than placebo recipients. Also, more orlistat- than placebo-treated patients improved from diabetic status to normal or impaired glucose tolerance (44.3 vs. 32.5%; P=0.0763) after 24 weeks. Orlistat also produced improvements in lipid profiles and waist circumference.

CONCLUSIONS:

In combination with a mildly reduced-calorie diet, orlistat significantly reduces body weight, and improves glycaemic control and several cardiovascular risk factors in overweight and obese Chinese patients with newly diagnosed Type 2 diabetes.

• Authors: Y-F Shi, C-Y Pan, J Hill, Y Gao
• Journal: Diabetic medicine : a journal of the British Diabetic Association (Diabet Med) Vol. 22 Issue 12 Pg. 1737-43 (Dec 2005) ISSN: 0742-3071 [Print] England
• PMID: 16401321 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Obesity Agents
• Blood Glucose
• Glycated Hemoglobin A
• Lactones
• Orlistat

Topics

• Adolescent
• Adult
• Aged
• Anti-Obesity Agents (therapeutic use)
• Asian People
• Blood Glucose (metabolism)
• Diabetes Mellitus, Type 2 (diet therapy, drug therapy)
• Diet, Reducing
• Female
• Glycated Hemoglobin (metabolism)
• Humans
• Lactones (therapeutic use)
• Male
• Middle Aged
• Obesity (diet therapy, drug therapy)
• Orlistat
• Prospective Studies
• Weight Loss (drug effects)