Abstract | OBJECTIVE: To compare tissue markers of collagen metabolism in the uterosacral ligaments with those in vaginal tissue in women with uterine prolapse. DESIGN: Prospective observational experimental study. SETTING: A tertiary urogynaecology unit. POPULATION: METHODS: MAIN OUTCOME MEASURES: RESULTS: Fourteen women with prolapse and 14 women without prolapse (controls) were included. A significant increase in pro MMP-2 expression was seen in vaginal tissue from women with prolapse (P < 0.05) but not activated MMP-2, MMP-9 and TIMP-2. For uterosacral ligaments, the differences were not statistically significant. No significant difference in hydroxyproline content was found between control and prolapse in either tissue. Significant correlations exist in expression of pro-MMP-2, activated MMP-2, MMP-9 and TIMP-2 in vaginal tissue with that in uterosacral ligaments. CONCLUSIONS: Correlations existed between markers of collagen metabolism in the vaginal and uterosacral tissues. This suggests vaginal tissue reflects the endopelvic fascia. The changes which are more pronounced in vaginal tissue may be as a result of prolapse rather than cause.
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Authors | Christian H Phillips, Fred Anthony, Chris Benyon, Ash K Monga |
Journal | BJOG : an international journal of obstetrics and gynaecology
(BJOG)
Vol. 113
Issue 1
Pg. 39-46
(Jan 2006)
ISSN: 1470-0328 [Print] England |
PMID | 16398770
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Tissue Inhibitor of Metalloproteinase-2
- Collagen
- Matrix Metalloproteinases
- Hydroxyproline
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Biomarkers
(metabolism)
- Collagen
(metabolism)
- Female
- Humans
- Hydroxyproline
(metabolism)
- Ligaments
(metabolism)
- Matrix Metalloproteinases
(metabolism)
- Middle Aged
- Prospective Studies
- Sacrum
(metabolism)
- Skin
(metabolism)
- Tissue Inhibitor of Metalloproteinase-2
(metabolism)
- Uterine Prolapse
(metabolism)
- Uterus
(metabolism)
- Vagina
(metabolism)
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