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Pioglitazone: a review of its use in type 2 diabetes mellitus.

Abstract
Pioglitazone is an antihyperglycaemic agent that, in the presence of insulin resistance, increases hepatic and peripheral insulin sensitivity, thereby inhibiting hepatic gluconeogenesis and increasing peripheral and splanchnic glucose uptake. Pioglitazone is generally well tolerated, weight gain and oedema are the most common emergent adverse events, and there are no known drug interactions between pioglitazone and other drugs. In clinical trials in patients with type 2 diabetes mellitus, pioglitazone as monotherapy, or in combination with metformin, repaglinide, insulin or a sulphonylurea, induced both long- and short-term improvements in glycaemic control and serum lipid profiles. Pioglitazone was also effective in reducing some measures of cardiovascular risk and arteriosclerosis. Pioglitazone thus offers an effective treatment option for the management of patients with type 2 diabetes.
AuthorsJohn Waugh, Gillian M Keating, Greg L Plosker, Stephanie Easthope, Dean M Robinson
JournalDrugs (Drugs) Vol. 66 Issue 1 Pg. 85-109 ( 2006) ISSN: 0012-6667 [Print] New Zealand
PMID16398569 (Publication Type: Journal Article, Review)
Chemical References
  • Blood Glucose
  • Hypoglycemic Agents
  • Lipids
  • Thiazolidinediones
  • Pioglitazone
Topics
  • Blood Glucose (metabolism)
  • Cardiovascular Diseases (etiology, prevention & control)
  • Diabetes Mellitus, Type 2 (blood, complications, drug therapy)
  • Drug Therapy, Combination
  • Drug Tolerance
  • Dyslipidemias (blood, complications, drug therapy)
  • Economics, Pharmaceutical
  • Humans
  • Hypoglycemic Agents (administration & dosage, pharmacology, therapeutic use)
  • Insulin Resistance
  • Lipids (blood)
  • Pioglitazone
  • Randomized Controlled Trials as Topic
  • Thiazolidinediones (administration & dosage, pharmacology, therapeutic use)

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