Abstract |
Vascular endothelial growth factor A ( VEGF-A) plays an essential role in tumor progression through stromal neovascularization in malignant solid tumors. Neuropilin (NRP) is considered to be the specific receptor for limited types of VEGF-A isoform, VEGF165. The clinicopathological implications of NRP are not well understood in colon cancer, while almost all colon cancers overexpressed VEGF-A. We examined the expression levels of NRP1 and NRP2 genes in 54 colon cancer cases and paired extraneoplastic tissue with quantitative real-time polymerase chain reaction. The gene expression levels of NRP1 in the tumor (0.431+/-0.583) were significantly decreased compared to those in the extraneoplastic tissue (0.754+/-0.799) (paired t-test, p=0.0208). On the other hand, the gene expression levels of NRP2 in the tumor (0.763+/-0.791) were not decreased compared to those in the extraneoplastic tissue (0.508+/-0.386) (paired t-test, p=0.0511). Twenty cases, with preserved expression of the NRP1 gene in the tumor, showed a better prognosis as compared to the 34 cases with decreased NRP1 expression (p=0.0258, log-rank test). No significant relationship was noted between NRP2 gene expression and prognosis. The results suggested that preserved NRP1 expression provides colon cancer patients with a better prognosis.
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Authors | Takashi Kamiya, Tsutomu Kawakami, Yoshiyuki Abe, Masatake Nishi, Noboru Onoda, Noriyuki Miyazaki, Yasuhisa Oida, Hitoshi Yamazaki, Yoshito Ueyama, Masato Nakamura |
Journal | Oncology reports
(Oncol Rep)
Vol. 15
Issue 2
Pg. 369-73
(Feb 2006)
ISSN: 1021-335X [Print] Greece |
PMID | 16391856
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers, Tumor
- Neuropilin-2
- VEGFA protein, human
- Vascular Endothelial Growth Factor A
- Neuropilin-1
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Topics |
- Adenocarcinoma
(metabolism, mortality, pathology)
- Biomarkers, Tumor
(analysis)
- Colonic Neoplasms
(metabolism, mortality, pathology)
- Gene Expression
- Humans
- Neuropilin-1
(biosynthesis)
- Neuropilin-2
(biosynthesis)
- Prognosis
- Reverse Transcriptase Polymerase Chain Reaction
- Survival Analysis
- Vascular Endothelial Growth Factor A
(biosynthesis)
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