Abstract |
Comparative study of the antiulcer and antisecretory activity of Asparagus racemosus Willd (Shatawari) and Withania somnifera Dunal ( Ashwagandha) root extract with a standard drug, ranitidine, in various models of gastric ulcer in rats is presented. Ulcer was induced by the indomethacin ( NSAID) and swim (restraint) stress treatment. Results demonstrated that A. racemosus as well as W. somnifera methanolic extract (100 mg/kg BW/day p.o.) given orally for 15 days significantly reduced the ulcer index, volume of gastric secretion, free acidity, and total acidity. A significant increase in the total carbohydrate and total carbohydrate/ protein ratio was also observed. Study also indicated an increase in antioxidant defense, that is, enzymes superoxide dismutase, catalase, and ascorbic acid, increased significantly, whereas a significant decrease in lipid peroxidation was observed. A. racemosus was more effective in reducing gastric ulcer in indomethacin-treated gastric ulcerative rats, whereas W. somnifera was effective in stress-induced gastric ulcer. Results obtained for both herbal drugs were comparable to those of the standard drug ranitidine.
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Authors | Maheep Bhatnagar, Siddhraj S Sisodia, Rekha Bhatnagar |
Journal | Annals of the New York Academy of Sciences
(Ann N Y Acad Sci)
Vol. 1056
Pg. 261-78
(Nov 2005)
ISSN: 0077-8923 [Print] United States |
PMID | 16387694
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antioxidants
- Oxidants
- Plant Extracts
- Catalase
- Superoxide Dismutase
- Indomethacin
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Topics |
- Animals
- Antioxidants
(pharmacology)
- Asparagus Plant
- Catalase
(metabolism)
- Female
- Gastrointestinal Contents
(drug effects)
- Indomethacin
(pharmacology)
- Liver
(drug effects, enzymology)
- Male
- Oxidants
(pharmacology)
- Peptic Ulcer
(prevention & control)
- Plant Extracts
(pharmacology)
- Rats
- Rats, Wistar
- Superoxide Dismutase
(drug effects, metabolism)
- Withania
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