Treatment of short gut syndrome with early living related small bowel transplantation.

Abstract

AIM:

To investigate the results of treating short bowel syndrome with an early living related small bowel transplantation (SBT).

METHODS:

A 17-year-old boy with a 20-cm-long residual intestine due to necrotic volvulus received an early living related SBT from his mother. Donor-specific blood transfusion was performed for 8 weeks before transplantation, each time for 50 mL every week. Cytomegalovirus status in both donor and recipient was negative. A 160-cm distal ileal segment was removed from the donor. The graft ilecolic artery and vein were anastomosed to the recipient's infrarenal aorta and caval vein. The proximal end of the graft was anastomosed end-to-end to the residual recipient jejunum; the distal anastomosis, between the distal end of the graft and transverse colon. An ileostomy was also performed. Immunosuppression, infection prophylaxis, and antithrombotic and nutrition support were given postoperatively.

RESULTS:

The donor had an uneventful recovery. No technical complications were observed. The recipient was alive and well at 31 weeks after the operation. No graft rejection or infection was observed. He was off TPN 8 weeks after the operation and took low-fat food. The D-xylose test in the recipient was almost normal.

CONCLUSIONS:

Early living related small intestine transplantation is a good treatment for short bowel syndrome.

• Authors: S F Wang, X M Che, J C Chen, S Y Lu, L Fan, R Wang, G W Li
• Journal: Transplantation proceedings (Transplant Proc) Vol. 37 Issue 10 Pg. 4461-3 (Dec 2005) ISSN: 0041-1345 [Print] United States
• PMID: 16387145 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunosuppressive Agents

Topics

• Adolescent
• Antibiotic Prophylaxis
• Drug Therapy, Combination
• Humans
• Ileum (blood supply, surgery)
• Immunosuppressive Agents (therapeutic use)
• Living Donors
• Male
• Necrosis
• Short Bowel Syndrome (pathology, surgery)
• Tissue and Organ Harvesting (methods)
• Treatment Outcome
• Vena Cava, Inferior (surgery)