HLA alleles and risk of cervical intraepithelial neoplasia among southwestern American Indian women.

Abstract	An increase in cervical intraepithelial neoplasia (CIN) has been described in American Indian women in New Mexico. Differences in human leukocyte antigen (HLA) alleles have been reported in cervical intraepithelial neoplasia (CIN) compared with controls in other populations. We investigated HLA alleles and CIN in Southwest American Indian women. The case control study included 89 women with biopsy-proven CIN II/III (diagnosed November 1994 through October 1997) and 271 similar women with normal cervical epithelium from the same clinics. DRB1, DQB1, and DPB1 alleles were determined using DNA typing techniques. DQA1 and HLA-A allele typing was included for some subjects (randomly chosen n = 37 and n = 163 cases and controls, respectively). We found a decreased risk of CIN with DRB11402 (OR 0.5, 95% CI 0.3-0.9) and an increased risk with DRB11501 (OR 2.7, 95% CI 0.9-7.3). Additionally, DQA10102 was associated with increased risk (OR 4.5, 95% CI 1.3-5.3) and HLA-A02 with decreased risk (OR 0.4, CI 0.2-0.9). Our findings are discussed along with studies in other populations.
Authors	Melissa A Schiff, Raymond J Apple, Patricia Lin, J Lee Nelson, Cosette M Wheeler, Thomas M Becker
Journal	Human immunology (Hum Immunol) Vol. 66 Issue 10 Pg. 1050-6 (Oct 2005) ISSN: 0198-8859 [Print] United States
PMID	16386646 (Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural)
Chemical References	HLA-A Antigens HLA-DP Antigens HLA-DP beta-Chains HLA-DPB1 antigen HLA-DQ Antigens HLA-DQ alpha-Chains HLA-DQ beta-Chains HLA-DQA1 antigen HLA-DQB1 antigen HLA-DR Antigens HLA-DRB1 Chains Membrane Glycoproteins
Topics	Adolescent Adult Alleles Case-Control Studies Confidence Intervals Female Gene Frequency Genetic Predisposition to Disease HLA-A Antigens (genetics) HLA-DP Antigens (genetics) HLA-DP beta-Chains HLA-DQ Antigens (genetics) HLA-DQ alpha-Chains HLA-DQ beta-Chains HLA-DR Antigens (genetics) HLA-DRB1 Chains Haplotypes Humans Indians, North American Membrane Glycoproteins (genetics) Middle Aged Neoplasm Staging New Mexico Odds Ratio Risk Factors Uterine Cervical Neoplasms (ethnology, genetics, pathology)

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