[Biologic therapy with anti-TNFα in spondyloarthritides and other autoimmune diseases].

Abstract

OBJECTIVE:

To evaluate the efficacy of the anti-TNFα (Tumor Necrosis Factor alpha) drugs in a variety of pathologic conditions such as psoriatic arthritis, undifferentiated entheso-arthritides, chronic inflammatory bowel diseases, adult onset Still's disease, Behcet disease.

METHODS:

Review of all published studies evaluating the efficacy of these drugs (mainly infliximab and etanercept, adalimumab to a lesser degree) on the above diseases.

RESULTS:

Results are reported for each pathologic condition. Both drugs showed to be very efficacious in all the above conditions, except Crohn disease where etanercept does not seem adequate.

CONCLUSIONS:

Both drugs work extremely well, even though comparison between infliximab and etanercept efficacy cannot be performed, due to the lack of a direct comparison.

• Authors: G Lapadula
• Journal: Reumatismo (Reumatismo) Vol. 57 Issue 4 Suppl Pg. 22-9 ( 2005) ISSN: 0048-7449 [Print] Italy
• Vernacular Title: La terapia biologica con anti-TNFα nelle spondiloartriti e in altre malattie autoimmuni.
• PMID: 16385352 (Publication Type: Comparative Study, English Abstract, Journal Article, Review)

Chemical References

• Adrenal Cortex Hormones
• Anti-Inflammatory Agents, Non-Steroidal
• Antibodies, Monoclonal
• Antibodies, Monoclonal, Humanized
• Antirheumatic Agents
• Immunoglobulin G
• Immunosuppressive Agents
• Receptors, Tumor Necrosis Factor
• Receptors, Tumor Necrosis Factor, Type II
• Tumor Necrosis Factor-alpha
• Infliximab
• Adalimumab
• Etanercept

Topics

• Adalimumab
• Adrenal Cortex Hormones (administration & dosage, therapeutic use)
• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, therapeutic use)
• Antibodies, Monoclonal (pharmacology, therapeutic use)
• Antibodies, Monoclonal, Humanized
• Antirheumatic Agents (pharmacology, therapeutic use)
• Arthritis, Psoriatic (drug therapy)
• Autoimmune Diseases (drug therapy)
• Behcet Syndrome (drug therapy)
• Biological Therapy
• Clinical Trials as Topic (statistics & numerical data)
• Crohn Disease (drug therapy)
• Double-Blind Method
• Etanercept
• Humans
• Immunoglobulin G (pharmacology, therapeutic use)
• Immunosuppressive Agents (administration & dosage, therapeutic use)
• Infliximab
• Multicenter Studies as Topic (statistics & numerical data)
• Randomized Controlled Trials as Topic (statistics & numerical data)
• Receptors, Tumor Necrosis Factor (therapeutic use)
• Receptors, Tumor Necrosis Factor, Type II (antagonists & inhibitors)
• Spondylarthritis (drug therapy)
• Treatment Outcome
• Tumor Necrosis Factor-alpha (antagonists & inhibitors)