Antibody pretargeting advances cancer radioimmunodetection and radioimmunotherapy.

Abstract

This article reviews the methods of pretargeting, which involve separating the targeting antibody from the subsequent delivery of an imaging or therapeutic agent that binds to the tumor-localized antibody. This provides enhanced tumor:background ratios and the delivery of a higher therapeutic dose than when antibodies are directly conjugated with radionuclides, as currently practiced in cancer radioimmunotherapy. We describe initial promising clinical results using streptavidin-antibody constructs with biotin-radionuclide conjugates in the treatment of patients with malignant gliomas, and of bispecific antibodies with hapten-radionuclides in the therapy of tumors expressing carcinoembryonic antigen, such as medullary thyroid and small-cell lung cancers.

• Authors: David M Goldenberg, Robert M Sharkey, Giovanni Paganelli, Jacques Barbet, Jean-François Chatal
• Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (J Clin Oncol) Vol. 24 Issue 5 Pg. 823-34 (Feb 10 2006) ISSN: 1527-7755 [Electronic] United States
• PMID: 16380412 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Review)

Chemical References

• Antibodies, Neoplasm
• Haptens
• Indicators and Reagents
• Streptavidin

Topics

• Antibodies, Neoplasm (immunology)
• Carcinoma, Non-Small-Cell Lung (diagnostic imaging, therapy)
• Clinical Trials as Topic
• Glioma (diagnostic imaging, therapy)
• Haptens
• Humans
• Indicators and Reagents
• Lung Neoplasms (diagnostic imaging, therapy)
• Radioimmunodetection (methods)
• Radioimmunotherapy (methods)
• Streptavidin
• Thyroid Neoplasms (diagnostic imaging, therapy)