Abstract |
Previous studies have shown a good outcome for patients who present with normal findings on stress myocardial perfusion imaging. Currently, the prognostic implications of a normal study in patients who have a history of coronary artery disease (CAD) are not clear. This study investigated the long-term prognosis after a normal finding on stress technetium-99m (Tc-99m)-tetrofosmin single-photon emission computed tomography in patients with a history of CAD. The study included 147 consecutive patients with a history of CAD (previous myocardial infarction and/or myocardial revascularization), who underwent exercise bicycle or high-dose dobutamine- atropine stress Tc-99m-tetrofosmin single-photon emission computed tomography, and had normal perfusion results during stress and at rest. Follow-up was completed in all patients. During a follow-up of 6.5 +/- 1.9 years, 20 patients (14%) died, 10 (7%) of whom died due to cardiac causes, and 12 (8%) had a nonfatal myocardial infarction. Annual cardiac death rates were 0.5% during the first 3 years of follow-up and 1.3% in the subsequent 3 years. Independent predictors of cardiac death were male gender, rate-pressure product at rest, and rate-pressure product at peak stress. In conclusion, patients who have a history of CAD have a very low cardiac death rate during the 3 years after a normal finding on stress Tc-99m-tetrofosmin single-photon emission computed tomography. Repeated testing should be reconsidered 3 years after the initial evaluation and when a change in symptoms or clinical condition occurs.
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Authors | Arend F L Schinkel, Abdou Elhendy, Jeroen J Bax, Ron T van Domburg, Aukje Huurman, Roelf Valkema, Elena Biagini, Vittoria Rizzello, Harm H Feringa, Eric P Krenning, Maarten L Simoons, Don Poldermans |
Journal | The American journal of cardiology
(Am J Cardiol)
Vol. 97
Issue 1
Pg. 1-6
(Jan 01 2006)
ISSN: 0002-9149 [Print] United States |
PMID | 16377272
(Publication Type: Journal Article)
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Chemical References |
- Organophosphorus Compounds
- Organotechnetium Compounds
- Radiopharmaceuticals
- technetium tc-99m tetrofosmin
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Topics |
- Aged
- Blood Pressure
- Coronary Artery Disease
(mortality, therapy)
- Coronary Circulation
- Echocardiography, Stress
- Exercise Test
- Female
- Follow-Up Studies
- Heart Rate
- Humans
- Male
- Middle Aged
- Multivariate Analysis
- Myocardial Infarction
(diagnostic imaging, mortality, therapy)
- Myocardial Revascularization
- Organophosphorus Compounds
- Organotechnetium Compounds
- Prognosis
- Radiopharmaceuticals
- Sex Factors
- Tomography, Emission-Computed, Single-Photon
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