Lisuride treatment of restless legs syndrome: first studies with monotherapy in de novo patients and in combination with levodopa in advanced disease.

Abstract

In two 4-week polysomnography pilot studies with 10 patients each, we investigated the efficacy of oral lisuride as monotherapy in de novo RLS patients as well as in combination with levodopa in advanced RLS. Daily doses at study end were 0.3 mg lisuride, plus 150 mg levodopa in the combination study. Marked improvements occurred in both studies in different PLM indexes and in the CGI. Levodopa dose could be decreased by 27%. Lisuride might be an efficacious treatment for RLS in general, and in combination with levodopa in advanced stage.

• Authors: H Benes, A Deissler, A Rodenbeck, A Engfer, R Kohnen
• Journal: Journal of neural transmission (Vienna, Austria : 1996) (J Neural Transm (Vienna)) Vol. 113 Issue 1 Pg. 87-92 (Jan 2006) ISSN: 0300-9564 [Print] Austria
• PMID: 16372146 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Levodopa
• Lisuride

Topics

• Adult
• Aged
• Drug Therapy, Combination
• Female
• Humans
• Levodopa (administration & dosage)
• Lisuride (administration & dosage)
• Male
• Middle Aged
• Pilot Projects
• Polysomnography (drug effects)
• Restless Legs Syndrome (drug therapy, physiopathology)
• Single-Blind Method