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Hereditary periodic fever syndrome sans fever or distinct periodicity presenting with psychosis.

Abstract
The genetic basis for several hereditary periodic fever syndromes has been identified and consequently, the phenotypic spectrum of these disorders has broadened. We describe a young woman with tumor necrosis factor receptor-associated periodic syndrome (TRAPS), proven by mutational analysis, who presented with psychosis but without fever, symptom periodicity, or similar family medical history. This patient represents the first case of TRAPS-associated psychosis. This case illustrates the importance of mutation analysis for this group of disorders in individuals presenting with unexplained inflammatory symptoms and recurrent psychoses.
AuthorsMiriam Hurst, Keith Hull, Dave Nicholls, Rohan Ameratunga
JournalJournal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases (J Clin Rheumatol) Vol. 11 Issue 6 Pg. 329-30 (Dec 2005) ISSN: 1076-1608 [Print] United States
PMID16371805 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Immunoglobulin G
  • Immunologic Factors
  • Receptors, Tumor Necrosis Factor
  • Receptors, Tumor Necrosis Factor, Type I
  • Recombinant Fusion Proteins
  • DNA
  • Etanercept
Topics
  • Adolescent
  • DNA (analysis)
  • DNA Mutational Analysis
  • Diagnosis, Differential
  • Etanercept
  • Familial Mediterranean Fever (complications, diagnosis, drug therapy)
  • Female
  • Follow-Up Studies
  • Humans
  • Immunoglobulin G (therapeutic use)
  • Immunologic Factors (therapeutic use)
  • Periodicity
  • Psychotic Disorders (diagnosis, drug therapy, etiology)
  • Receptors, Tumor Necrosis Factor (therapeutic use)
  • Receptors, Tumor Necrosis Factor, Type I (genetics)
  • Recombinant Fusion Proteins (therapeutic use)
  • Recurrence

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