Abstract |
The genetic basis for several hereditary periodic fever syndromes has been identified and consequently, the phenotypic spectrum of these disorders has broadened. We describe a young woman with tumor necrosis factor receptor-associated periodic syndrome (TRAPS), proven by mutational analysis, who presented with psychosis but without fever, symptom periodicity, or similar family medical history. This patient represents the first case of TRAPS-associated psychosis. This case illustrates the importance of mutation analysis for this group of disorders in individuals presenting with unexplained inflammatory symptoms and recurrent psychoses.
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Authors | Miriam Hurst, Keith Hull, Dave Nicholls, Rohan Ameratunga |
Journal | Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases
(J Clin Rheumatol)
Vol. 11
Issue 6
Pg. 329-30
(Dec 2005)
ISSN: 1076-1608 [Print] United States |
PMID | 16371805
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Immunoglobulin G
- Immunologic Factors
- Receptors, Tumor Necrosis Factor
- Receptors, Tumor Necrosis Factor, Type I
- Recombinant Fusion Proteins
- DNA
- Etanercept
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Topics |
- Adolescent
- DNA
(analysis)
- DNA Mutational Analysis
- Diagnosis, Differential
- Etanercept
- Familial Mediterranean Fever
(complications, diagnosis, drug therapy)
- Female
- Follow-Up Studies
- Humans
- Immunoglobulin G
(therapeutic use)
- Immunologic Factors
(therapeutic use)
- Periodicity
- Psychotic Disorders
(diagnosis, drug therapy, etiology)
- Receptors, Tumor Necrosis Factor
(therapeutic use)
- Receptors, Tumor Necrosis Factor, Type I
(genetics)
- Recombinant Fusion Proteins
(therapeutic use)
- Recurrence
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