HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Cerebral oxygen supply during hypotension in near-term lambs: a near-infrared spectroscopy study.

Abstract
Sufficient O(2)-supply to the brain is necessary for an adequate cerebral energy metabolism, function and growth. To elucidate the relation between changes in, respectively, mean arterial blood pressure (MABP) and cerebral O(2)-supply and changes in the oxygenation state of hemoglobin during hypotension in preterm born lambs. Preterm lambs were delivered at 141 days (n=7) or 127 days (n=7) of gestation. Hypotension was induced by stepwise withdrawal of blood. Cerebral arterial blood gases were analyzed at the end of each level to calculate cerebral O(2)-supply. Near-infrared spectroscopy was used to measure changes in the concentration of cerebral oxyhemoglobin (cO(2)Hb), deoxyhemoglobin (cHHb) and cHbD (the difference between cO(2)Hb and cHHb). In the 141 and the 127 d lambs, changes in MABP and cerebral O(2)-supply were positively linearly related with DeltacO(2)Hb, and negatively with DeltacHHb. MABP was positively linearly related with changes in cHbD. During hemorrhagic hypotension, changes in MABP and cerebral O(2)-supply are reflected by changes in the oxygenation state of cerebral hemoglobin in near-term born lambs.
AuthorsSandra Van Os, John Klaessens, Jeroen Hopman, Djien Liem, Margot Van De Bor
JournalBrain & development (Brain Dev) Vol. 28 Issue 2 Pg. 115-21 (Mar 2006) ISSN: 0387-7604 [Print] Netherlands
PMID16368208 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Hemoglobins
  • Oxyhemoglobins
  • Angiotensin Amide
  • Oxygen
Topics
  • Angiotensin Amide (metabolism)
  • Animals
  • Animals, Newborn
  • Blood Pressure (physiology)
  • Cerebral Cortex (metabolism)
  • Female
  • Hemoglobins (analysis)
  • Male
  • Oxygen (metabolism)
  • Oxygen Consumption
  • Oxyhemoglobins (analysis)
  • Pregnancy
  • Sheep
  • Spectroscopy, Near-Infrared

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: