Abstract | OBJECTIVE: METHODS: This prospective study included 16 myasthenic patients, tested audiologically twice, first after improvement from myasthenic crisis or acute oropharyngeal dysfunction (1 week from admission) and then 2 months later. We detected the effect of contralateral acoustic stimulation (CAS) on patients' transient and distortion product otoacoustic emissions (TEOAE and DPOAE). RESULTS: Compared with controls, patients reported significant reduction in overall echo response and amplitude of TEOAEs at 1-2 kHz and at 1-6 kHz of DPOAE with marked reduction at 5 kHz. In the control group, CAS produced amplitude reduction in TEOAEs and DPOAEs at 1-4 kHz. Utilizing masking effect, patients reported amplitude reduction in TEOAEs at 1.5-4 kHz while DPOAEs did not reach significant level except at 1.5 and 5 kHz. After 2 months, no changes were observed compared with early assessment. CONCLUSIONS: It is clear that disease progression is associated with irreversible cochlear damage. Lack of improvement in patients' emissions despite partial non-audiometric improvement in relation to receptors needs to be considered.
|
Authors | S A Hamed, A M Elattar, E A Hamed |
Journal | Acta neurologica Scandinavica
(Acta Neurol Scand)
Vol. 113
Issue 1
Pg. 46-54
(Jan 2006)
ISSN: 0001-6314 [Print] Denmark |
PMID | 16367899
(Publication Type: Controlled Clinical Trial, Journal Article)
|
Topics |
- Adolescent
- Adult
- Auditory Threshold
- Chronic Disease
- Cochlea
(pathology, physiopathology)
- Diagnostic Techniques, Otological
- Female
- Follow-Up Studies
- Hearing Loss, Sensorineural
(diagnosis, etiology, physiopathology)
- Humans
- Male
- Middle Aged
- Myasthenia Gravis
(complications, physiopathology)
- Otoacoustic Emissions, Spontaneous
- Prospective Studies
|