Emollients in a propanol-based hand rub can significantly decrease irritant contact dermatitis.
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| Abstract |
The objective of this study is to determine the effect of emollients in a propanol-based hand rub on skin dryness and erythema. In this prospective, randomized, controlled, double-blind trial, 35 subjects participated; of them approximately half were atopic (modified Erlanger atopy score > or =8). 2 propanol-based formulations were tested in a repeated open application test, 1 contained a mixture of emollients (0.81%, w/w). 2 aliquots of 0.7 ml of each formulation were applied twice per day over 2 weeks to the cubital fossa of each subject after random assignment of the preparations. Treatment areas were assessed before each application and 3 days postfinal application by visual inspection for erythema and dryness according to a standard scale. The sum score over all assessment time-points served as primary parameter. The mean sum score for erythema and dryness was significantly lower for the hand rub with emollients (0.8 +/- 2.4) in comparison with that for the hand rub without emollients (1.5 +/- 3.5; P = 0.022; Wilcoxon signed rank test). A comparison of the atopic and non-atopic subjects revealed no significant difference for any of the products (P > 0.05; Mann-Whitney U-test). It is concluded that the addition of emollients to a propanol-based hand rub can significantly decrease irritant contact dermatitis under frequent-use conditions.
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| Authors | Günter Kampf, Walter Wigger-Alberti, Volker Schoder, Klaus-Peter Wilhelm |
| Journal | Contact dermatitis (Contact Dermatitis) Vol. 53 Issue 6 Pg. 344-9 (Dec 2005) ISSN: 0105-1873 [Print] England |
| PMID | 16364124 (Publication Type: Journal Article, Randomized Controlled Trial) |
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