Abstract | BACKGROUND: METHODS: To study the way in which the acute-phase response induced by sterile tissue injury influences pulmonary host defense, mice were injected subcutaneously with turpentine or saline in both hind limbs either 2 or 5 days before intranasal inoculation with A. baumannii. RESULTS: CONCLUSIONS: These data suggest that the acute-phase response and SAA inhibit the local inflammatory response to A. baumannii pneumonia, which may facilitate bacterial outgrowth.
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Authors | Rosemarijn Renckens, Joris J T H Roelofs, Sylvia Knapp, Alex F de Vos, Sandrine Florquin, Tom van der Poll |
Journal | The Journal of infectious diseases
(J Infect Dis)
Vol. 193
Issue 2
Pg. 187-95
(Jan 15 2006)
ISSN: 0022-1899 [Print] United States |
PMID | 16362882
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Chemokines
- Cytokines
- Irritants
- Proteins
- Recombinant Proteins
- Serum Amyloid A Protein
- Peroxidase
- Turpentine
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Topics |
- Acinetobacter Infections
(immunology, pathology)
- Acinetobacter baumannii
(immunology)
- Acute-Phase Reaction
(immunology)
- Animals
- Bronchoalveolar Lavage Fluid
(chemistry)
- Chemokines
(analysis)
- Cross Infection
- Cytokines
(analysis)
- Disease Models, Animal
- Humans
- Irritants
(administration & dosage, pharmacology)
- Lung
(pathology)
- Mice
- Mice, Inbred C57BL
- Neutrophil Infiltration
- Peroxidase
(analysis)
- Pneumonia, Bacterial
(immunology, pathology)
- Proteins
(analysis)
- Recombinant Proteins
(administration & dosage)
- Serum Amyloid A Protein
(administration & dosage, physiology)
- Turpentine
(administration & dosage, pharmacology)
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