Abstract | BACKGROUND: Experimental studies have shown that mechanical ventilation using high tidal volumes (V(T)) damages the lungs, causing pulmonary edema. We tested the hypothesis that high V(T) ventilation in rats induces major vascular dysfunction. METHODS: Healthy Sprague-Dawley rats, weighing (mean +/- SD) 340 +/- 15 g, were ventilated with either V(T) = 9 mL/kg and positive end-expiratory pressure (PEEP) = 8 (n = 8) or V(T) = 35 mL/kg and PEEP = 0 (n = 8). The high V(T) used in the injurious ventilation group is in the V(T) range used in other studies to induce lung damage in a short period of time in rats. Lungs were removed for examination under light microscopy and vascular rings from the thoracic aorta were studied for isometric tension recording. RESULTS: CONCLUSION:
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Authors | Nicolás Nin, José A Valero, José A Lorente, Marta de Paula, Pilar Fernández-Segoviano, Alberto Sánchez-Ferrer, Andrés Esteban |
Journal | The Journal of trauma
(J Trauma)
Vol. 59
Issue 3
Pg. 711-6
(Sep 2005)
ISSN: 0022-5282 [Print] United States |
PMID | 16361917
(Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Analysis of Variance
- Animals
- Aorta, Thoracic
(pathology)
- Lung
(blood supply, pathology)
- Male
- Photomicrography
- Random Allocation
- Rats
- Rats, Sprague-Dawley
- Respiration, Artificial
(adverse effects, methods)
- Tidal Volume
- Vascular Diseases
(etiology, pathology)
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