Abstract | OBJECTIVE: METHODS: RESULTS: Endothelial dependent vasodilatation (EDV) improved significantly within 24 hours of infliximab infusion. The median change in red blood cell flux (interquartile range) was 5.7 (4.3-8.2) before infusion v 8.4 (7.5-10.9) at 24 hours; p=0.027. This was not maintained at day 14. No improvement was seen in EDV after cyclophosphamide plus methylprednisolone infusion. CONCLUSION: The rapid but transient improvement in EDV after TNFalpha inhibition suggests that TNFalpha may have a direct role in the impairment of endothelial function.
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Authors | K Raza, D M Carruthers, R Stevens, A D Filer, J N Townend, P A Bacon |
Journal | Annals of the rheumatic diseases
(Ann Rheum Dis)
Vol. 65
Issue 7
Pg. 946-8
(Jul 2006)
ISSN: 0003-4967 [Print] England |
PMID | 16361277
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Monoclonal
- Antirheumatic Agents
- Immunosuppressive Agents
- Tumor Necrosis Factor-alpha
- Cyclophosphamide
- Infliximab
- Methylprednisolone
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Topics |
- Adult
- Aged
- Antibodies, Monoclonal
(therapeutic use)
- Antirheumatic Agents
(therapeutic use)
- Arteritis
(drug therapy, immunology)
- Cyclophosphamide
(therapeutic use)
- Endothelium, Vascular
(drug effects, immunology)
- Female
- Humans
- Immunosuppressive Agents
(therapeutic use)
- Infliximab
- Laser-Doppler Flowmetry
- Male
- Methylprednisolone
(therapeutic use)
- Middle Aged
- Pilot Projects
- Statistics, Nonparametric
- Time Factors
- Tumor Necrosis Factor-alpha
(antagonists & inhibitors, immunology)
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