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The combined effect of iloprost and N-acetylcysteine in preventing spinal cord ischemia in rabbits.

AbstractOBJECTIVES:
This study investigated the cytoprotective effects of N-acetylcysteine (NAC) and iloprost on spinal cord ischemia in an experimental model.
MATERIALS AND METHODS:
Thirty-five (male) New Zealand white rabbits were included in five study groups (n=7, each group). One group served as Sham. Rabbits in other groups had their abdominal aorta cross-clamped just above the iliac bifurcation for 40 min. During aortic cross clamping, iloprost, NAC, both iloprost and NAC or saline (control) were infused.
RESULTS:
In NAC, iloprost, and iloprost+NAC groups, neurological status of rabbits (Tarlov score) 24 and 48 h after the operation was better than the control group (p<0.01), but worse than the Sham group (p<0.01). There was minimal neuronal damage in the iloprost treated groups compared to the NAC group (p<0.05). Mean viability index values in NAC, iloprost and iloprost+NAC groups were higher than the control group (p<0.01). Viability index in the NAC group was lower than the iloprost and iloprost+NAC groups.
CONCLUSIONS:
The use of iloprost and NAC may provide better protection from spinal cord ischemia.
AuthorsM Boga, B Discigil, E A Ozkisacik, U Gurcun, M I Badak, E Dikicioglu, C Yenisey, I Meteoglu
JournalEuropean journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery (Eur J Vasc Endovasc Surg) Vol. 31 Issue 4 Pg. 366-72 (Apr 2006) ISSN: 1078-5884 [Print] England
PMID16359890 (Publication Type: Journal Article)
Chemical References
  • Vasodilator Agents
  • Nitric Oxide
  • Phosphopyruvate Hydratase
  • Iloprost
  • Acetylcysteine
Topics
  • Acetylcysteine (pharmacology)
  • Animals
  • Cytoprotection
  • Iloprost (pharmacology)
  • Ischemia (complications, prevention & control)
  • Male
  • Models, Animal
  • Nitric Oxide (blood)
  • Paraplegia (etiology, prevention & control)
  • Phosphopyruvate Hydratase (blood)
  • Rabbits
  • Random Allocation
  • Spinal Cord (blood supply, pathology)
  • Vasodilator Agents (pharmacology)

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