Abstract | OBJECTIVES: MATERIALS AND METHODS: Thirty-five (male) New Zealand white rabbits were included in five study groups (n=7, each group). One group served as Sham. Rabbits in other groups had their abdominal aorta cross-clamped just above the iliac bifurcation for 40 min. During aortic cross clamping, iloprost, NAC, both iloprost and NAC or saline (control) were infused. RESULTS: In NAC, iloprost, and iloprost+NAC groups, neurological status of rabbits (Tarlov score) 24 and 48 h after the operation was better than the control group (p<0.01), but worse than the Sham group (p<0.01). There was minimal neuronal damage in the iloprost treated groups compared to the NAC group (p<0.05). Mean viability index values in NAC, iloprost and iloprost+NAC groups were higher than the control group (p<0.01). Viability index in the NAC group was lower than the iloprost and iloprost+NAC groups. CONCLUSIONS:
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Authors | M Boga, B Discigil, E A Ozkisacik, U Gurcun, M I Badak, E Dikicioglu, C Yenisey, I Meteoglu |
Journal | European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery
(Eur J Vasc Endovasc Surg)
Vol. 31
Issue 4
Pg. 366-72
(Apr 2006)
ISSN: 1078-5884 [Print] England |
PMID | 16359890
(Publication Type: Journal Article)
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Chemical References |
- Vasodilator Agents
- Nitric Oxide
- Phosphopyruvate Hydratase
- Iloprost
- Acetylcysteine
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Topics |
- Acetylcysteine
(pharmacology)
- Animals
- Cytoprotection
- Iloprost
(pharmacology)
- Ischemia
(complications, prevention & control)
- Male
- Models, Animal
- Nitric Oxide
(blood)
- Paraplegia
(etiology, prevention & control)
- Phosphopyruvate Hydratase
(blood)
- Rabbits
- Random Allocation
- Spinal Cord
(blood supply, pathology)
- Vasodilator Agents
(pharmacology)
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