Beneficial effects of Zingiber officinale Roscoe on fructose induced hyperlipidemia and hyperinsulinemia in rats.

Abstract

Fructose supplementation produced cardinal features of Syndrome-X including significant elevations in seum cholesterol, triglyceride, glucose and insulin and also in body weight. While treatment with methanolic extract of dried rhizomes of Zingiber officinale produced a significant reduction in fructose induced elevation in lipid levels, bodyweight, hyperglycemia and hyperinsulinemia, treatment with ethyl acetate extract of Z officinale did not poduce any significant change in either of the last two parameters. However, it produced a significant reduction in elevated lipid levels and body weight The concentration of 6-gingerol was found to be higher in methanolic extract and less in ethyl acetate extract. The results suggest that the methanolic extract of Z officinale produces better effects as compared to ethyl acetate extract in fructose induced hyperlipidemia associated with insulin resistance. The extent of activity appears to be dependent on the concentration of 6-gingerol present in the extracts.

• Authors: Sanjay V Kadnur, Ramesh K Goyal
• Journal: Indian journal of experimental biology (Indian J Exp Biol) Vol. 43 Issue 12 Pg. 1161-4 (Dec 2005) ISSN: 0019-5189 [Print] India
• PMID: 16359128 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Catechols
• Fatty Alcohols
• Plant Extracts
• Fructose
• gingerol

Topics

• Animals
• Body Weight (physiology)
• Catechols
• Diabetes Mellitus, Experimental (diet therapy)
• Fatty Alcohols (analysis)
• Fructose (toxicity)
• Ginger (chemistry)
• Hyperinsulinism (blood, diet therapy)
• Hyperlipidemias (diet therapy)
• Metabolic Syndrome (diet therapy)
• Plant Extracts (administration & dosage)
• Rats
• Rhizome (chemistry)