Effect of diet and tylosin on chronic diarrhea in beagles.

Abstract

Seven beagles in a colony of dogs had chronic diarrhea for at least 30 days. The dogs were subsequently treated with tylosin 20 mg/kg BW q24h PO for 10 days. During the treatment period, the feces became firmer but remained loose. When the treatment was discontinued, the diarrhea reappeared in 3 weeks. The feces remained abnormally loose in all dogs treated with metronidazole, trimethoprim-sulfadiazine, or doxycycline and prednisone. The diet was then changed for 10 days from a highly digestible moist pet food to a dry food developed for normal adult dogs. The feces again became firmer, although still loose in some dogs. The period was then extended to 3 month, but the fecal consistency continued to fluctuate from ideal to diarrhea. The dogs were treated a 2nd time with tylosin 20 mg/kg BW q24h PO for 10 days. The feces then became significantly firmer and remained so throughout a 3-month follow-up. We conclude that the combination of diet and tylosin was more effective than either agent alone in control of chronic diarrhea.

• Authors: Elias Westermarck, Rafael Frias, Teresa Skrzypczak
• Journal: Journal of veterinary internal medicine (J Vet Intern Med) 2005 Nov-Dec Vol. 19 Issue 6 Pg. 822-7 ISSN: 0891-6640 [Print] United States
• PMID: 16355675 (Publication Type: Clinical Trial, Comparative Study, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Tylosin

Topics

• Animal Feed
• Animals
• Anti-Bacterial Agents (therapeutic use)
• Chronic Disease (therapy)
• Diarrhea (diet therapy, drug therapy, therapy, veterinary)
• Diet (veterinary)
• Dog Diseases (diet therapy, drug therapy, therapy)
• Dogs
• Drug Therapy, Combination
• Feces (chemistry)
• Tylosin (therapeutic use)