Serum hepatocyte growth factor activator inhibitor type I (HAI-I) and type 2 (HAI-2) in prostate cancer.

Abstract

BACKGROUND:

Hepatocyte growth factor activator inhibitor type 1 (HAI-1) and type 2 (HAI-2) are Kunitz-type serine protease inhibitors for hepatocyte growth factor activator (HGFA). We attempted to clarify whether serum levels of HAI-1 and HAI-2 could be a useful marker in patients with prostate cancer.

METHODS:

Serum levels of HAI-1 and HAI-2 were measured by enzyme-linked immunosorbent assay in 27 patients with benign prostatic hyperplasia (BPH) and 118 patients with prostate cancer.

RESULTS:

The mean serum levels of HAI-1 in patients with prostate cancer were significantly higher than those in patients with BPH. Furthermore, the serum HAI-1 levels in patients with distant metastasis and hormone resistant prostate cancer were significantly elevated compared with those in patients with organ-confined diseases. There were no significant differences in serum HAI-2 levels among prostate cancer subgroups according to clinical stage. Significantly elevated levels of HAI-1 were detected in 38 patients with prostate cancer before any treatment.

CONCLUSIONS:

HAI-1 may be a potential tumor marker for prostate cancer. Further studies in large groups of patients are needed to define the clinical value of HAI-1.

• Authors: Osamu Nagakawa, Toshiya Yamagishi, Takuya Akashi, Kazuhiro Nagaike, Hideki Fuse
• Journal: The Prostate (Prostate) Vol. 66 Issue 5 Pg. 447-52 (Apr 01 2006) ISSN: 0270-4137 [Print] United States
• PMID: 16353247 (Publication Type: Comparative Study, Journal Article)
• Copyright: (c) 2005 Wiley-Liss, Inc.

Chemical References

• Biomarkers, Tumor
• Membrane Glycoproteins
• Proteinase Inhibitory Proteins, Secretory
• SPINT1 protein, human
• SPINT2 protein, human
• Trypsin Inhibitor, Kunitz Soybean

Topics

• Biomarkers, Tumor (blood)
• Enzyme-Linked Immunosorbent Assay
• Humans
• Male
• Membrane Glycoproteins (blood)
• Neoplasm Staging
• Prostatic Neoplasms (blood, pathology)
• Proteinase Inhibitory Proteins, Secretory
• Reference Values
• Reproducibility of Results
• Trypsin Inhibitor, Kunitz Soybean (blood)