[A case of recurrent colon cancer responding completely to uracil/tegafur (UFT) plus oral leucovorin (LV) therapy].

Abstract

The patient was a 78-year-old woman who underwent right hemicolectomy with lymph node dissection (D 2) for cecal cancer in June 2003. Histological diagnosis was moderately differentiated adenocarcinoma, ss, n(-), P 0, H 0, M (-), stage II. Adjuvant chemotherapy was not conducted, and the patient was periodically observed after operation. In April 2004, the serum CEA level was elevated to 14.9 ng/ml. Abdominal CT examinations revealed a tumor, 50 x 35 x 50 mm in size, on the right iliopsoas muscle close to the anastomotic site. Systemic chemotherapy with UFT + Leucovorin was initiated under the diagnosis of local recurrence. Only grade 1 body weight loss,pigmentation, pruritus, and anorexia were recognized during chemotherapy. However, these complications did not require administration. After completion of 6 courses of this chemotherapeutic regimen,the serum CEA level was normalized at 3.1 ng/ml, and CT scan revealed the tumor had disappeared in November 2004. Currently, the patient is free from any signs of recurrence and has maintained a complete remission (CR).

• Authors: Tsunekazu Mizushima, Toshikazu Ito, Hitoshi Mizuno, Yoshihito Souma, Satoshi Kainuma, Hiroaki Yamanaka, Hideto Ozawa, Takashi Kanou, Yasuhiro Nakamori, Kazuhiro Iwase
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 32 Issue 13 Pg. 2129-31 (Dec 2005) ISSN: 0385-0684 [Print] Japan
• PMID: 16352943 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Drug Combinations
• UFT(R) drug
• Tegafur
• Uracil
• Leucovorin

Topics

• Adenocarcinoma (drug therapy, surgery)
• Aged
• Antineoplastic Combined Chemotherapy Protocols
• Colectomy
• Colonic Neoplasms (drug therapy, surgery)
• Combined Modality Therapy
• Drug Administration Schedule
• Drug Combinations
• Female
• Humans
• Leucovorin (administration & dosage)
• Lymph Node Excision
• Neoplasm Recurrence, Local (drug therapy)
• Remission Induction
• Tegafur (administration & dosage)
• Uracil (administration & dosage)