Abstract | OBJECTIVES: METHODS: All women with a diagnosis of uterine cancer at Memorial Sloan-Kettering Cancer Center between 1980 and June 2004 with a past history of breast cancer treated with tamoxifen were identified. Clinical and pathologic data were obtained through retrospective chart review. RESULTS: There were 106 women identified with a history of breast cancer treated with tamoxifen preceding their diagnosis of uterine cancer. Thirty-nine (37%) developed uterine cancer more than 12 months after discontinuing tamoxifen. The median time until developing uterine cancer in past users was 33 months (range, 13-22). There were no significant differences in age at breast cancer diagnosis, body mass index, parity, stage of breast cancer, modality of breast cancer treatment, or duration of tamoxifen therapy between past and recent users of tamoxifen. Women who were past users of tamoxifen had significantly more FIGO (International Federation of Gynecology and Obstetrics) grade 3 and non-endometrioid histologic subtypes (P = 0.009; P = 0.007). CONCLUSIONS: More than one third of women treated with tamoxifen develop uterine cancer more than 12 months after discontinuing therapy. These women are at greater risk of developing moderately to poorly differentiated tumors, which is a known poor prognostic factor. Therefore, women with a past history of tamoxifen therapy should have continued surveillance after completion of tamoxifen to ensure early diagnosis of uterine cancer.
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Authors | Sarah E Ferguson, Robert A Soslow, Alison Amsterdam, Richard R Barakat |
Journal | Gynecologic oncology
(Gynecol Oncol)
Vol. 101
Issue 2
Pg. 322-6
(May 2006)
ISSN: 0090-8258 [Print] United States |
PMID | 16352333
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
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Topics |
- Aged
- Breast Neoplasms
(drug therapy, surgery)
- Chemotherapy, Adjuvant
- Female
- Humans
- Middle Aged
- Retrospective Studies
- Tamoxifen
(adverse effects, therapeutic use)
- Uterine Neoplasms
(chemically induced, pathology)
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