Coxiella burnetii vascular graft infection.

Abstract

BACKGROUND:

Coxiella burnetii, the causative agent of Q fever, may cause culture-negative vascular graft infections. Very few cases of C. burnetii infection of a vascular graft have been reported. All were diagnosed by serology.

CASE PRESENTATION:

We report the first case of Coxiella burnetii vascular graft infection diagnosed by broad-range PCR and discuss the diagnostic approaches and treatment strategies of chronic C. burnetii infection.

CONCLUSION:

C. burnetii should be considered as etiological agent in patients with a vascular graft and fever, abdominal pain, and laboratory signs of inflammation, with or without exposure history. Broad-range PCR should be performed on culture-negative surgical samples in patients with suspected infection of vascular graft.

• Authors: Laurence Senn, Mario Franciolli, Didier Raoult, Alexandre Moulin, Ludwig Von Segesser, Thierry Calandra, Gilbert Greub
• Journal: BMC infectious diseases (BMC Infect Dis) Vol. 5 Pg. 109 (Dec 07 2005) ISSN: 1471-2334 [Electronic] England
• PMID: 16336642 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibodies, Bacterial
• RNA, Ribosomal, 16S
• Chloroquine
• Doxycycline

Topics

• Antibodies, Bacterial (blood)
• Aorta, Abdominal (pathology, surgery)
• Aortic Aneurysm, Abdominal (surgery)
• Blood Vessel Prosthesis (microbiology)
• Chloroquine (administration & dosage)
• Coxiella burnetii (drug effects, immunology, isolation & purification)
• Doxycycline (administration & dosage)
• Femoral Artery (surgery)
• Humans
• Male
• Middle Aged
• Polymerase Chain Reaction
• Prosthesis-Related Infections (diagnosis, drug therapy, microbiology)
• Q Fever (diagnosis, drug therapy)
• RNA, Ribosomal, 16S
• Treatment Outcome