Abstract | BACKGROUND: METHODS:
Cancer registry data from 1988-2000 were linked with AIDS registry data from 1981 to July 2003 for San Diego County to identify 537 AIDS-NHL patients. By using the total number of patients with AIDS who were alive as of July 1 annually as the AIDS population denominator, the average annual incidence of NHL was estimated among patients with AIDS for the pre- HAART period (1988-1995) and post- HAART period (1996-2000). The chi-square test was used to compare proportions, and a Cox proportional hazards model was used to compare survival between the pre- HAART and post- HAART periods. RESULTS: The incidence of NHL decreased from 29.6 per 1000 person-years pre- HAART to 6.5 per 1000 person-years post- HAART. The proportion of patients who had NHL of central nervous system (CNS) origin decreased from 28% pre- HAART to 17% post- HAART. Among patients with systemic NHL, 54% received chemotherapy pre- HAART, and 72% received chemotherapy post- HAART. The percentage of intermediate-grade NHL increased from 33% pre- HAART to 49% post- HAART, and the percentage of high-grade NHL decreased from 38% to 19%, respectively. A diagnosis of human immunodeficiency virus infection preceding the NHL diagnosis and Stage IV NHL were associated with worse survival, whereas a diagnosis of NHL in the post- HAART period and chemotherapy were associated with better survival. The median survival was 4 months pre- HAART and 9 months post- HAART. CONCLUSIONS: Since the introduction of HAART, there has been a decrease in the incidence of systemic and CNS NHL among patients with AIDS. Among patients with systemic, AIDS-related NHL, there has been decreased high-grade histology, increased use of chemotherapy, and improved survival.
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Authors | Catherine Diamond, Thomas H Taylor, Tabatha Aboumrad, Hoda Anton-Culver |
Journal | Cancer
(Cancer)
Vol. 106
Issue 1
Pg. 128-35
(Jan 01 2006)
ISSN: 0008-543X [Print] United States |
PMID | 16329140
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2005 American Cancer Society. |
Topics |
- Acquired Immunodeficiency Syndrome
(complications, drug therapy)
- Adult
- Antiretroviral Therapy, Highly Active
- Female
- Humans
- Incidence
- Lymphoma, AIDS-Related
(drug therapy, epidemiology, etiology)
- Male
- Registries
- Survival Rate
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