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Dynamic modes of the cortical actomyosin gel during cell locomotion and division.

Abstract
Tight regulation of the contractility of the actomyosin cortex is essential for proper cell locomotion and division. Enhanced contractility leads, for example, to aberrations in the positioning of the mitotic spindle or to anomalous migration modes that allow tumor cells to escape anti-dissemination treatments. Spherical membrane protrusions called blebs occasionally appear during cell migration, cell division or apoptosis. We have shown that the cortex ruptures at sites where actomyosin cortical contractility is increased, leading to the formation of blebs. Here, we propose that bleb formation, which releases cortical tension, can be used as a reporter of cortical contractility. We go on to analyze the implications of spontaneous cortical contractile behaviors on cell locomotion and division and we particularly emphasize that variations in actomyosin contractility can account for a variety of migration modes.
AuthorsEwa Paluch, Cécile Sykes, Jacques Prost, Michel Bornens
JournalTrends in cell biology (Trends Cell Biol) Vol. 16 Issue 1 Pg. 5-10 (Jan 2006) ISSN: 0962-8924 [Print] England
PMID16325405 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Contractile Proteins
  • Cytoskeletal Proteins
  • Gels
  • Actomyosin
Topics
  • Actomyosin (analysis, physiology, ultrastructure)
  • Animals
  • Cell Division (physiology)
  • Cell Membrane (chemistry, physiology, ultrastructure)
  • Cell Movement (physiology)
  • Cell Polarity
  • Contractile Proteins (analysis, physiology, ultrastructure)
  • Cytokinesis
  • Cytoplasm (chemistry, ultrastructure)
  • Cytoskeletal Proteins (analysis, physiology, ultrastructure)
  • Cytoskeleton (chemistry, physiology, ultrastructure)
  • Gels
  • Humans

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