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Resistance to cisatracurium in a patient with MELAS syndrome.

Abstract
There are conflicting reports on the response of mitochondrial myopathy patients to the neuromuscular blocking drugs, showing either normal response or marked sensitivity. We present a patient with MELAS syndrome who underwent Nissen fundoplication and gastrojejunostomy. Marked resistance to the nondepolarizing muscle relaxant, cisatracurium was observed. The anesthesia management, as well as the various causes of resistance to cisatracurium in this patient are discussed.
AuthorsMarie T Aouad, Frederic J Gerges, Anis S Baraka
JournalPaediatric anaesthesia (Paediatr Anaesth) Vol. 15 Issue 12 Pg. 1124-7 (Dec 2005) ISSN: 1155-5645 [Print] France
PMID16324037 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Neuromuscular Nondepolarizing Agents
  • Atracurium
  • cisatracurium
Topics
  • Adolescent
  • Atracurium (administration & dosage, analogs & derivatives)
  • Digestive System Surgical Procedures
  • Drug Resistance
  • Female
  • Humans
  • MELAS Syndrome (physiopathology, surgery)
  • Neuromuscular Junction (drug effects, physiopathology)
  • Neuromuscular Nondepolarizing Agents (administration & dosage)
  • Synaptic Transmission (drug effects)

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