Abstract | BACKGROUND:
Laryngospasm is a well-known problem typically occurring immediately following tracheal extubation. Propofol is known to inhibit airway reflexes. In this study, we sought to assess whether the empiric use of a subhypnotic dose of propofol prior to emergence will decrease the occurrence of laryngospasm following extubation in children. METHODS: After approval from the Institutional Ethics Committee and informed parental consent, we enrolled 120 children ASA physical status I and II, aged 3-14 years who were scheduled to undergo elective tonsillectomy with or without adenoidectomy under standard general anesthesia. Before extubation, the patients were randomized and received in a blinded fashion either propofol 0.5 mg.kg(-1) or saline (control) intravenously. Tracheal extubation was performed 60 s after administration of study drug, when the child was breathing regularly and reacting to the tracheal tube. RESULTS:
Laryngospasm was seen in 20% (n = 12) of the 60 children in the control group and in only 6.6% (n = 4) of 60 children in the propofol group (P < 0.05). CONCLUSIONS:
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Authors | Yatindra Kumar Batra, Maya Ivanova, Syed Shujat Ali, Mohammed Shamsah, Abdul Raheem Al Qattan, Kumar G Belani |
Journal | Paediatric anaesthesia
(Paediatr Anaesth)
Vol. 15
Issue 12
Pg. 1094-7
(Dec 2005)
ISSN: 1155-5645 [Print] France |
PMID | 16324030
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Hypnotics and Sedatives
- Propofol
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Topics |
- Adenoidectomy
- Adolescent
- Anesthesia, General
- Child
- Child, Preschool
- Device Removal
- Double-Blind Method
- Humans
- Hypnotics and Sedatives
(administration & dosage)
- Intubation, Intratracheal
- Laryngismus
(etiology, prevention & control)
- Postoperative Complications
(prevention & control)
- Propofol
(administration & dosage)
- Tonsillectomy
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