Effect of BN 52256 and other mediator antagonists on ouabain-induced ventricular fibrillation in sensitized guinea-pigs and on ischemia-induced fibrillation in rats.

Abstract

The threshold dose of ouabain necessary to induce ventricular fibrillation is decreased in sensitized guinea-pigs signalizing an enhanced arrhythmogenicity. Esculetine or WEB 2170 antagonists of histamine and PAF, respectively and especially a combination of both can increase the threshold dose of ouabain-induced fibrillation demonstrating an antiarrhythmic effect. BN 52256 a substance with multi-antagonistic properties shows antiarrhythmic effect in this method, too. WEB 2170 and BN 52256 decrease the incidence of ventricular fibrillation after coronary ligation in rats.

• Authors: H J Mest, T Rein, A Riedel, W Köpernik, C Braquet
• Journal: Agents and actions. Supplements (Agents Actions Suppl) Vol. 37 Pg. 228-34 ( 1992) ISSN: 0379-0363 [Print] Switzerland
• PMID: 1632298 (Publication Type: Journal Article)

Chemical References

• Anti-Arrhythmia Agents
• Azepines
• Organoselenium Compounds
• Piperidines
• Platelet Activating Factor
• Triazoles
• Umbelliferones
• BN 52256
• Ouabain
• Clemastine
• Propranolol
• bepafant
• esculetin

Topics

• Anesthesia
• Animals
• Anti-Arrhythmia Agents (pharmacology)
• Azepines (pharmacology)
• Clemastine (pharmacology)
• Coronary Disease (complications)
• Coronary Vessels (physiology)
• Guinea Pigs
• Organoselenium Compounds (pharmacology)
• Ouabain
• Piperidines (pharmacology)
• Platelet Activating Factor (antagonists & inhibitors)
• Propranolol (pharmacology)
• Rats
• Triazoles (pharmacology)
• Umbelliferones (pharmacology)
• Ventricular Fibrillation (chemically induced, etiology, prevention & control)