Abstract |
The antithrombotic efficacy of the prostacyclin analogue naxaprostene has been tested in rabbits with copper coil-induced carotid artery thrombosis. With oral pretreatment, 10 mg/kg naxaprostene prevented thrombotic arterial occlusion; with intraduodenal pretreatment the efficacy of naxaprostene was enhanced and 1 mg/kg was sufficient to exert an antithrombotic effect. The final average carotid blood flow at 180 min compared to the flow immediately before thrombus induction was 85 +/- 25% and 47 +/- 18% in animals treated with 10 mg/kg p.o. resp. 1 mg/kg i.d. naxaprostene. Parallel to the antithrombotic effect, naxaprostene inhibited ADP- and collagen-induced fall in circulating platelets. In anesthetized rabbits there was no dissociation between antithrombotic and hypotensive effects of naxaprostene.
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Authors | J Schneider |
Journal | Agents and actions. Supplements
(Agents Actions Suppl)
Vol. 37
Pg. 176-82
( 1992)
ISSN: 0379-0363 [Print] Switzerland |
PMID | 1632291
(Publication Type: Journal Article)
|
Chemical References |
- Fibrinolytic Agents
- Adenosine Diphosphate
- naxaprostene
- Collagen
- Epoprostenol
|
Topics |
- Adenosine Diphosphate
(pharmacology)
- Administration, Oral
- Animals
- Blood Pressure
(drug effects)
- Carotid Artery Thrombosis
(physiopathology)
- Collagen
(pharmacology)
- Duodenum
- Epoprostenol
(administration & dosage, analogs & derivatives, pharmacology)
- Fibrinolytic Agents
(administration & dosage, pharmacology)
- Intubation, Gastrointestinal
- Male
- Rabbits
- Thrombocytopenia
(blood)
|