[Moexipril influence on quality of life in postmenopausal women with arterial hypertension].

Abstract

AIM:

To evaluate a hypotensive effect and metabolic neutrality and safety of ACE inhibitor moexipril in postmenopausal women with arterial hypertension (AH), influence on quality of life.

MATERIAL AND METHODS:

Thirty two hypertensive postmenopausal women (age 63.1 +/- 0.8 years) received moexipril for 4 months. The history of AH was 10.4 +/- 2.3 years, on the average. After a free of drugs week moexipril was given in a dose 7.5 mg/day with titration to 15 mg in 2 weeks and addition (if the target pressure was not achieved) of hydrochlorothiaside in a dose 12.5 mg. The examination included 24-h monitoring of blood pressure, estimation of microalbuminuria (MAU), endothelial function and blood biochemistry. Initially and after 4 weeks of the treatment quality of life was assessed (scales SF-36 and EuroQol).

RESULTS:

The initial level of office BP was 164.33/94.50 mm Hg, in 3 months a target level was achieved (136/84 mm Hg). It persisted for the next month. Moexipril corrected endothelial function and vascular elasticity in all the patients. MAU fell from 28.28 to 8.10 mg/l. Quality of life improved. Lipid and carbohydrate changes were not registered.

CONCLUSION:

Moexipril has a hypotensive and nephroprotective effects, improves endothelial function and quality of life in hypertensive postmenopausal women.

• Authors: Iu B Belousov, M G Glezer, E B Tkhostova, M A Demidova
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 77 Issue 10 Pg. 75-8 ( 2005) ISSN: 0040-3660 [Print] Russia (Federation)
• PMID: 16320692 (Publication Type: English Abstract, Journal Article)

Chemical References

• Angiotensin-Converting Enzyme Inhibitors
• Tetrahydroisoquinolines
• moexipril

Topics

• Angiotensin-Converting Enzyme Inhibitors (therapeutic use)
• Female
• Follow-Up Studies
• Humans
• Hypertension (drug therapy)
• Middle Aged
• Postmenopause
• Quality of Life
• Tetrahydroisoquinolines (therapeutic use)
• Time Factors
• Treatment Outcome