HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Expression and function of somatostatin receptors in peripheral nerve sheath tumors.

Abstract
Although somatostatin receptors have been detected in many normal and neoplastic tissues, little is known of their expression and function in peripheral nerve tumors. In the present study, we examined the expression of all 5 somatostatin receptor subtypes (sst1-5) in 3 normal peripheral nerves, 3 traumatic neuromas, 27 schwannomas, 18 neurofibromas, and 177 malignant peripheral nerve sheath tumors (MPNSTs) by immunohistochemistry as well as by Western blot and reverse transcriptase-polymerase chain reaction investigations in 2 normal peripheral nerves, one neurofibroma, 5 schwannomas, and 5 MPNSTs. Immunoreactive somatostatin receptors were not detectable in normal peripheral nerve and in nonneoplastic Schwann cell proliferations. In contrast, sst2A mRNA and protein was present in 89% of schwannomas. This receptor subtype was less frequently detected in neurofibromas (22%) and MPNSTs (15%). Interestingly, sst4 was seen in 32% of MPNSTs and was almost exclusively expressed in this malignant tumor type. In support of a role in Schwann cell tumor growth control by somatostatin was the observation of induced internalization of sst2A and inhibition of cell proliferation in an NF1-associated MPNST cell line. Moreover, administration of an sst2A-selective agonist resulted in induction of MPNST cell apoptosis. We conclude that peripheral nerve sheath tumors often express at least one functional somatostatin receptor. Furthermore, our findings suggest a potential clinical role for somatostatin receptor agonists in tumor imaging and/or treatment of schwannomas and MPNSTs.
AuthorsChristian Mawrin, Stefan Schulz, Anja Hellwig-Patyk, Elmar Kirches, Albert Roessner, Uwe Lendeckel, Raimund Firsching, Christian K Vorwerk, Gerburg Keilhoff, Knut Dietzmann, Kirsten Grimm, Guy Lindberg, David H Gutmann, Bernd W Scheithauer, Arie Perry
JournalJournal of neuropathology and experimental neurology (J Neuropathol Exp Neurol) Vol. 64 Issue 12 Pg. 1080-8 (Dec 2005) ISSN: 0022-3069 [Print] England
PMID16319718 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Protein Isoforms
  • RNA, Messenger
  • Receptors, Somatostatin
Topics
  • Animals
  • Blotting, Western
  • Cells, Cultured
  • Disease Progression
  • Humans
  • Immunohistochemistry
  • Male
  • Nerve Sheath Neoplasms (metabolism, pathology)
  • Neurilemmoma (metabolism)
  • Neurofibromatosis 1 (metabolism, pathology)
  • Peripheral Nerves (metabolism)
  • Protein Isoforms (metabolism)
  • RNA, Messenger (metabolism)
  • Rats
  • Rats, Wistar
  • Receptors, Somatostatin (genetics, metabolism)
  • Reverse Transcriptase Polymerase Chain Reaction
  • Tissue Distribution

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: