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Influence of the hemoglobin solution HBOC-201 on tissue oxygenation in the rat R1H-tumor.

AbstractBACKGROUND:
HBOC-201 is an ultra purified bovine hemoglobin solution. It has already been used in clinical phase II/III trials for emergency treatments. Animal experiments have shown that HBOC-201 is highly effective in tissue oxygenation. The study was performed in order to assess the potential of low dose HBOC-201 to improve tumor oxygenation.
METHODS:
30 rats with a subcutaneously growing rhabdomyosarcoma R1H tumor were randomly assigned either to be ventilated with carbogen (n = 10), or to receive an IV injection of 0.3 g/kg HBOC-201 (n = 10) or a combination of 0.3 g/kg HBOC-201 and carbogen breathing (n = 10). Under general anesthesia the effects of the respective treatment on the tissue oxygen tension (tpO2) of the tumor were determined using a flexible stationary probe at baseline (b) and 15 and 60 min after application of the respective medication.
RESULTS:
HBOC-201 alone failed to improve tumor tpO2 (b: 1.3 +/- 1.2mmHg; 15min: 1.4 +/- 1 mmHg; 60min: 1 +/- 1 mmHg). In combination with carbogen the mean tpO2 of the tumor raised in comparison to baseline values (b: 3.1 +/- 4.6 mmHg; mmHg; 15min: 8.5 +/- 11*mmHg; 60min: 4.8 +/- 5mmHg; *p < 0.05 vs. b), but this effect was less pronounced than the increase in tpO2 by carbogen alone (b: 3.4 +/- 3.4mmHg; 15min: 9 +/- 10* mmHg; 60 min: 13 +/- 19* mmHg; *p < 0.05 vs. b).
CONCLUSION:
The application of low dose hemoglobin solution HBOC-201 does not result in improvement of tissue oxygenation in the rat rhabdomyosarcoma R1H.
AuthorsAndré Gottschalk, Annette Raabe, Matthias Hommel, Christian Rempf, Marc Freitag, Thomas Standl
JournalArtificial cells, blood substitutes, and immobilization biotechnology (Artif Cells Blood Substit Immobil Biotechnol) Vol. 33 Issue 4 Pg. 379-89 ( 2005) ISSN: 1073-1199 [Print] England
PMID16317957 (Publication Type: Journal Article)
Chemical References
  • Blood Substitutes
  • Hemoglobins
  • Carbon Dioxide
  • HBOC 201
  • carbogen
  • Oxygen
Topics
  • Animals
  • Blood Substitutes (administration & dosage, pharmacology)
  • Carbon Dioxide (administration & dosage, pharmacology)
  • Drug Evaluation, Preclinical
  • Hemoglobins (administration & dosage, pharmacology)
  • Hypoxia (drug therapy)
  • Oxygen (administration & dosage, metabolism, pharmacology)
  • Rats
  • Rhabdomyosarcoma (metabolism, pathology)
  • Tissue Distribution (drug effects)

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