Thymic carcinoma in a child with HIV infection.

Abstract

HIV infection predisposes to cancer during childhood. In addition to the AIDS-defining non-Hodgkin lymphoma (NHL) and Kaposi sarcoma, a range of other lymphoid malignancies and solid tumors have been described. We report the first case of an HIV-positive child with thymic carcinoma in the setting of regressing thymic cysts. The tumor expressed CKIT but failed to respond to imatinab mesylate after a transient response to multiagent chemotherapy. This case extends the spectrum of pediatric malignancy in the setting of HIV and suggests that patients with presumed benign thymic cysts require ongoing surveillance.

• Authors: Morgan McDonald, Thomas McLean, Thomas Belhorn, Scott Victor Smith, Lynn Ansley Fordham, Charles Woods, Julie Blatt
• Journal: Pediatric blood & cancer (Pediatr Blood Cancer) Vol. 49 Issue 7 Pg. 1004-7 (Dec 2007) ISSN: 1545-5009 [Print] United States
• PMID: 16317759 (Publication Type: Case Reports, Journal Article)
• Copyright: 2007 Wiley-Liss, Inc

Chemical References

• Antineoplastic Agents
• Benzamides
• Piperazines
• Pyrimidines
• Imatinib Mesylate

Topics

• Antineoplastic Agents (therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Benzamides
• Child
• Disease Progression
• Follow-Up Studies
• HIV Infections (complications, diagnosis, therapy)
• Humans
• Imatinib Mesylate
• Liver Neoplasms (diagnosis, secondary)
• Lung Neoplasms (diagnosis, secondary)
• Male
• Mediastinal Cyst (complications, diagnosis)
• Piperazines (therapeutic use)
• Pyrimidines (therapeutic use)
• Remission Induction
• Thymoma (complications, diagnosis, therapy)
• Thymus Neoplasms (complications, diagnosis, therapy)
• Tomography, X-Ray Computed
• Treatment Outcome