HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Early nephropathy in type 1 diabetes: a new perspective on who will and who will not progress.

Abstract
Impaired renal function and end-stage renal disease (ESRD) affect up to a third of patients with type 1 diabetes. Thus, strategies for early detection and for preventative interventions are of critical importance. A model of diabetic nephropathy was developed in the 1980s that placed paramount importance on the finding of microalbuminuria as an early marker of a committed process of progressive kidney disease in diabetes. However, recent studies have provided evidence that microalbuminuria is a marker of dynamic, rather than fixed, kidney injury. Preliminary studies into early renal function decline, a process measured in early nephropathy using a simple assay for cystatin C to calculate the slope of glomerular filtration rate change over time, suggest that it is a more proximal marker than microalbuminuria of a person's trajectory toward impaired renal function and ESRD. Therefore, early renal function decline, rather than microalbuminuria, may be considered as the early marker of the committed process underlying progressive diabetic nephropathy.
AuthorsBruce A Perkins, Andrzej S Krolewski
JournalCurrent diabetes reports (Curr Diab Rep) Vol. 5 Issue 6 Pg. 455-63 (Dec 2005) ISSN: 1534-4827 [Print] United States
PMID16316598 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Biomarkers
  • CST3 protein, human
  • Cystatin C
  • Cystatins
  • Protease Inhibitors
Topics
  • Albuminuria (complications, urine)
  • Biomarkers (blood, urine)
  • Cystatin C
  • Cystatins (blood)
  • Diabetes Mellitus, Type 1 (complications, metabolism, physiopathology)
  • Diabetic Nephropathies (etiology, metabolism, physiopathology)
  • Disease Progression
  • Glomerular Filtration Rate (physiology)
  • Humans
  • Prognosis
  • Protease Inhibitors (blood)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: