Mutations in TLR4 signaling that lead to increased susceptibility to infection in humans: an overview.

Abstract

In this overview, we will present current information on known mutations in the TLR4 signaling pathway that have been associated with increased susceptibility to disease. To date, mutations in the extracellular domain of TLR4 itself, IRAK-4, NEMO (IKK gamma), and I kappa B alpha have been identified and profoundly affect the host response to infection.

• Authors: Stefanie N Vogel, Agnes A Awomoyi, Prasad Rallabhandi, Andrei E Medvedev
• Journal: Journal of endotoxin research (J Endotoxin Res) Vol. 11 Issue 6 Pg. 333-9 ( 2005) ISSN: 0968-0519 [Print] United States
• PMID: 16303088 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)

Chemical References

• Toll-Like Receptor 4

Topics

• Disease Susceptibility
• Humans
• Infections (microbiology)
• Models, Biological
• Mutation
• Signal Transduction
• Toll-Like Receptor 4 (genetics, metabolism)