Determination of the minmum effective dosages of praziquantel, albendazole, and mebendazole against Clonorchis sinensis infection in rats.

Abstract

In order to determine the minimum effective dosages of praziquantel, albendazole, and mebendazole against Clonorchis sinensis infection in Sprague-Dawley rats, each rat was infected with 30 metacercariae and treated with one of three drugs. The rats were killed and examined 25 days after praziquantel treatment or 11 days after albendazole or mebendazole treatment. The minimum effective dosages were a single dose of praziquantel 375 mg/kg, albendazole 150 mg/kg, and mebendazole 150 mg/kg. Trials are required to determine whether these dosages are useful in the treatment of human clonorchiasis.

• Authors: Ping-Chin Fan, Chin-Cheng Wu, Ping Huang, Chih-Wei Yen
• Journal: The Kaohsiung journal of medical sciences (Kaohsiung J Med Sci) Vol. 21 Issue 10 Pg. 448-51 (Oct 2005) ISSN: 1607-551X [Print] China (Republic : 1949- )
• PMID: 16302447 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anthelmintics
• Praziquantel
• Mebendazole
• Albendazole

Topics

• Albendazole (administration & dosage, therapeutic use)
• Animals
• Anthelmintics (administration & dosage, therapeutic use)
• Clonorchiasis (drug therapy, parasitology)
• Clonorchis sinensis (drug effects)
• Dose-Response Relationship, Drug
• Male
• Mebendazole (administration & dosage, therapeutic use)
• Praziquantel (administration & dosage, therapeutic use)
• Rats
• Rats, Sprague-Dawley
• Treatment Outcome