Response to vinorelbine and low-dose cyclophosphamide chemotherapy in two patients with desmoplastic small round cell tumor.

Abstract

We report two cases of abdominal desmoplastic small round cell tumor (DSRCT) that showed a clinical response to the vinorelbine/low-dose cyclophosphamide combination that has been claimed to be effective for rhabdomyosarcoma. This observation may prompt further investigation into the activity of such a regimen in DSRCT patients with recurrent or refractory disease, with a view to a possible future role as maintenance therapy in controlling minimal residual disease in patients who achieve complete remission with intensive induction multimodality therapy.

• Authors: Andrea Ferrari, Federica Grosso, Silvia Stacchiotti, Cristina Meazza, Elena Zaffignani, Alfonso Marchianò, Michela Casanova
• Journal: Pediatric blood & cancer (Pediatr Blood Cancer) Vol. 49 Issue 6 Pg. 864-6 (Nov 2007) ISSN: 1545-5009 [Print] United States
• PMID: 16302215 (Publication Type: Case Reports, Journal Article)
• Copyright: (c) 2005 Wiley-Liss, Inc.

Chemical References

• Vinblastine
• Cyclophosphamide
• Vinorelbine

Topics

• Abdominal Neoplasms (diagnostic imaging, drug therapy, pathology)
• Adolescent
• Adult
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage)
• Biopsy, Fine-Needle
• Cyclophosphamide (administration & dosage)
• Humans
• Liver Neoplasms (diagnostic imaging, drug therapy, pathology)
• Male
• Neoplasm Metastasis
• Neoplasm, Residual
• Radiography
• Remission Induction
• Rhabdomyosarcoma (drug therapy)
• Sarcoma, Small Cell (diagnostic imaging, drug therapy, pathology)
• Vinblastine (administration & dosage, analogs & derivatives)
• Vinorelbine