Abstract | BACKGROUND: METHODS: RESULTS: hTERT staining was observed in most cells (>75%), in all but three lesions, and was of greater intensity in the nucleus, especially the nucleolus, compared with the cytoplasm. Spitz nevi tended to have weaker hTERT staining (mean = 1.7) compared with acquired nevi (mean = 2.2), dysplastic nevi (mean = 2.4), primary melanomas (mean = 2.4), or metastatic melanomas (mean = 3). CONCLUSIONS: Although telomerase activity was weaker in Spitz nevi, there was overlap with other nevi and primary invasive melanomas in our small series. Thus, hTERT expression does not appear to be a reliable adjunct to the histological diagnosis of primary melanocytic lesions.
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Authors | Douglas R Fullen, Weijian Zhu, Dafydd Thomas, Lyndon D Su |
Journal | Journal of cutaneous pathology
(J Cutan Pathol)
Vol. 32
Issue 10
Pg. 680-4
(Nov 2005)
ISSN: 0303-6987 [Print] United States |
PMID | 16293180
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- DNA-Binding Proteins
- Telomerase
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Topics |
- Cell Nucleus
(chemistry)
- DNA-Binding Proteins
(analysis)
- Diagnosis, Differential
- Dysplastic Nevus Syndrome
(diagnosis, enzymology, pathology)
- Humans
- Immunohistochemistry
- Melanocytes
(enzymology, pathology)
- Melanoma
(diagnosis, enzymology, pathology, secondary)
- Nevus
(chemistry, diagnosis, pathology)
- Nevus, Epithelioid and Spindle Cell
(diagnosis, enzymology, pathology)
- Nevus, Pigmented
(diagnosis, enzymology, pathology)
- Paraffin Embedding
- Reproducibility of Results
- Skin
(enzymology, pathology)
- Telomerase
(analysis)
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