Clindamycin in the treatment of group G beta-haemolytic streptococcal infections.

Abstract

We report a case of severe streptococcal cellulitis in a healthy 47 year old male, where the sole microbial isolate was a beta-haemolytic group G Streptococcus. Treatment failure with high dose penicillin was observed despite in vitro sensitivity. The addition of clindamycin resulted in dramatic clinical improvement. This may indicate an Eagle-type effect (whereby antibiotics exhibit paradoxically reduced bactericidal activities at high drug concentrations), in group G beta-haemolytic infections. Although well documented with group A streptococcal infections, this phenomenon has not been fully recognised with group G beta-haemolytic streptococcal infections. This may have important implications for clinical management.

• Authors: A Pillai, S Thomas, C Williams
• Journal: The Journal of infection (J Infect) Vol. 51 Issue 4 Pg. e207-11 (Nov 2005) ISSN: 1532-2742 [Electronic] England
• PMID: 16291271 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Clindamycin
• C-Reactive Protein

Topics

• Abscess (drug therapy, microbiology)
• Anti-Bacterial Agents (administration & dosage)
• C-Reactive Protein (analysis)
• Cellulitis (drug therapy, microbiology)
• Clindamycin (administration & dosage)
• Drug Therapy, Combination
• Erythema (pathology)
• Humans
• Leukocyte Count
• Male
• Middle Aged
• Streptococcal Infections (diagnosis, drug therapy, microbiology)
• Streptococcus (drug effects, isolation & purification)
• Treatment Outcome