Abstract |
A four-arm drug sensitivity study compared chloroquine, sulfadoxine-pyrimethamine (SP), mefloquine and mefloquine- artesunate in Sonitpur and Karbi Anglong districts in Assam state, India. Two criteria were used to ascertain outcome: success of clinical treatment and parasitologic cure. In Sonitpur, at 14 days, there were 36/56 early and late treatment failures plus late parasitologic failures to chloroquine and 16/56 for SP. In Karbi Anglong, combined treatment failure at 14 days was 16/56 to chloroquine and 8/60 to SP. Mefloquine and mefloquine- artesunate demonstrated 93.9% and 93.6% sustained responses respectively at 42 days. High failure rates to both chloroquine and SP preclude the use of these drugs as first-line treatment for uncomplicated falciparum malaria in this region. A mefloquine- artesunate combination presents an effective alternative utilizing the currently recommended higher dose of mefloquine.
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Authors | P Campbell, S Baruah, K Narain, C C Rogers |
Journal | Transactions of the Royal Society of Tropical Medicine and Hygiene
(Trans R Soc Trop Med Hyg)
Vol. 100
Issue 2
Pg. 108-18
(Feb 2006)
ISSN: 0035-9203 [Print] England |
PMID | 16289651
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Antimalarials
- Artemisinins
- Drug Combinations
- Quinolines
- Sesquiterpenes
- fanasil, pyrimethamine drug combination
- Artesunate
- Sulfadoxine
- Chloroquine
- Mefloquine
- Pyrimethamine
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Topics |
- Adolescent
- Antimalarials
(therapeutic use)
- Artemisinins
(therapeutic use)
- Artesunate
- Child
- Child, Preschool
- Chloroquine
(therapeutic use)
- Drug Combinations
- Drug Therapy, Combination
- Female
- Humans
- India
- Infant
- Malaria, Falciparum
(drug therapy)
- Male
- Mefloquine
(therapeutic use)
- Prospective Studies
- Pyrimethamine
(therapeutic use)
- Quinolines
(therapeutic use)
- Sesquiterpenes
(therapeutic use)
- Sulfadoxine
(therapeutic use)
- Treatment Outcome
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